Pure edge da forms
Therefore, there is an imperious necessity of looking for new alternative antibacterial materials and approaches capable of treating and preventing multidrug-resistant infections.Īntibacterials usually include antibiotics, antimicrobial peptides (AMPs), metal ions/oxides, and quaternary ammonium compounds. In fact, it has been estimated that deaths from microbial infections could surpass those from many other life-threatening diseases, such as cancer, by 2050 if no urgent actions are taken to address this serious situation. The World Health Organization has recently shown the high levels of antibiotic resistance in both developed and undeveloped countries. The CNFs used in this work were characterized by Raman spectroscopy and observed by high-resolution transmission electron with energy-disperse X-ray spectroscopy.ĭue to the capacity that bacteria possess of being able to develop antibiotic resistance by mutation, hospital associated infections, especially in immunocompromised and cancer patients, is increasingly spreading without suitable antibiotic therapy. In this study, these hollow filamentous materials, in direct contact with cells and loaded in the low-cost calcium alginate composite films, showed no cytotoxicity for human keratinocyte HaCaT cells, which render them very promising for biomedical applications. This Gram-positive bacterium is becoming one of the most dangerous pathogens, due to its abundance on skin.
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Thus, these nanomaterials, in pure form or incorporated in a minuscule amount into calcium alginate composite films to reduce production costs as much as possible, showed to be new weapons against a globally spreading multidrug-resistant pathogen, the methicillin-resistant Staphylococcus epidermidis (MRSE). Furthermore, here, the first report on the antibacterial activity of CNFs was demonstrated.
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In this regard, carbon nanofibers (CNFs) possess currently much lower cost than other carbon nanomaterials, such as graphene oxide, and exhibit excellent chemical, mechanical and electric properties. Due to the current global health problem of antibiotic resistant recently announced by the World Health Organization, there is an urgent necessity of looking for new alternative antibacterial materials able to treat and impede multidrug-resistant infections which are cost-effective and non-toxic for human beings.